In order to explore the potential relationship between the transcription factor p53 and miRNA expression in a colon cancer–related context, the human HCT-116 (wt-p53) and HCT-116 (null-p53) colon cancer cell lines were explored as model systems to investigate the role of p53 on the expression of miRNAs. This evidence concerns the gene TP53 and colonic neoplasm.