POMC and neoplasm: Even in tumor bearing anorectic rats, which showed significant weight loss due to tumor burden, similar results were seen: an increase of serotonin in PVN and VMN (ventromedial nucleus of hypothalamus) and a concomitant decrease of dopamine in PVN, VMN and LHA (lateral hypothalamus), and of NPY in LHA, VMN and PVN; a decrease in NPY in ARC and of POMC (proopiomelanocortin) in ARC and PVN [33,34] and these abnormalities reverted to normal after tumor resection.