This is supported by the observation that weight loss achieved by type 2 diabetes subjects was associated not only with a decrease in glycosylated hemoglobin (HbA1c), LDL cholesterol, insulin resistance, plasminogen activator inhibitor-1, CRP, IL-6, and TNF-α but also with significant improvements in arterial stiffness [21] suggesting that endothelial nitric oxide (eNO) production is increased whereas oxidative stress is decreased. The gene discussed is TNF; the disease is type 2 diabetes mellitus.