Genes involved in carbohydrate metabolism pathways, metabolism of cofactors and vitamins pathways, ubiquitin mediated proteolysis, signal transduction pathways, ECM-receptor interaction, neuroactive ligand receptor interaction, regulation of actin cytoskeleton, cell cycle, endocrine system pathways, nervous system pathways, Huntington's disease were upregulated in DNPH1 vs H. Genes involved in cell adhesion molecules (CAMs), antigen processing and presentation were downregulated in DNPH1 vs H. Here, RPS27A is linked to juvenile Huntington disease.