Since the first reports on this apoptosis-inducing function of Ad-mda7 numerous studies have been published demonstrating that IL-24, when administered in supra-physiological amounts via an adenoviral vector, selectively and efficiently kills cancer cell lines derived from breast, cervix, colon, lung, prostate, glioma, melanoma, ovary, bone, and other sources [10], [16], [18]–[25]. This evidence concerns the gene IL24 and central nervous system cancer.