Considering the calculations given by Kunz et al. [2] together with our very similar qPCR results it is sensible to assume that melanoma cells (and also immune cells) do not express functional receptor pairs that could transmit signals emanating from IL-24, a notion which is further substantiated by the lack of STAT3 activation in these cell types following IL-24 treatment. The gene discussed is STAT3; the disease is melanoma.