Also, transduction of lung cancer cells with Ad-IL-24 increased expression of ER stress-related proteins such as BiP/Grp78, GADD34, XBP-1 and transfection of cancer cells with ER-targeted IL-24 plasmids elicited increased apoptosis compared to proteins targeted to the nucleus or membrane [33]. The gene discussed is HSPA5; the disease is lung carcinoma.