Fig. 1B shows that IL-20 and IL-24 had no effect on melanoma lines, while IL-22 induced phosphorylation of STAT3 in A375 and Wm9 cells but not in Wm35 or MeWo. Control treatments with OSM and IFN-γ resulted in the expected activation patterns of STAT3, 1, and 5 [38], [39]. The gene discussed is STAT3; the disease is melanoma.