Parent over-rating was associated with greater intensity of pain (p = 0.01) and higher CHAQ score (p = 0.004), whereas physician over-rating was associated with greater severity of joint disease, as reflected by greater frequency of polyarticular involvement (i.e. ≥ 5 affected joints) and worse joint counts (p = 0.04 to <0.001), higher CRP (p = 0.03), higher frequency of Steinbrocker functional class = II (p < 0.001), and greater articular damage, as measured with the JADI (p < 0.001). This evidence concerns the gene CRP and arthropathy.