Annexin A2 shows increased expression in several type of cancer, including renal cell cancer (Zimmermann et al, 2004a), breast cancer (Sharma et al, 2006) and sarcomas (Gillette et al, 2004; Syed et al, 2007), and there are several possible mechanisms by which annexin A2 may be involved in tumour progression. The gene discussed is ANXA2; the disease is cancer.