Overexpression of annexin A2 has been found in renal cell cancer, where it is associated with tumour stage (Zimmermann et al, 2004a), invasive breast cancer (Sharma et al, 2006) and sarcomas, including both soft tissue sarcomas (Syed et al, 2007) and osteosarcomas (Gillette et al, 2004). This evidence concerns the gene ANXA2 and neoplasm.