A number of other immune genes, including MHC class I, components of the class I peptide presentation pathway (TAP1, TAP2, LMP2, LMP7 and Tapasin), B7-1/2, NKG2D ligands and certain tumor antigens, are also silenced by chromatin in multiple tumor types [12,14]. The gene discussed is PSMB8; the disease is neoplasm.