Support for the hypothesis that increased anxiety-like behaviour found in the rAAV-dnCaMKIV treated animals might be linked to acute reduction of CREB/CRE-dependent signaling in the NAc comes from a study in which herpes simplex virus-mediated expression of dominant-negative mutant of CREB in the NAc of adult mice and rats enhanced anxiogenic and aversive behavioural responses to emotional stimuli while overexpression of CREB had the opposite effect [9,10]. Here, CREB1 is linked to Anxiety.