However, additional studies on the effect of BTF-35 on a wide range of cell cycle associated proteins, NF-κB signaling pathways, Bcl-2 family proteins, caspases, and angiogenic chemokines are required to unravel the differential response of BTF-35 in normal versus cancer cells and confirm the mechanistic pathways of chemoprevention. This evidence concerns the gene NFKB1 and cancer.