TFPI2 and neoplasm: It had already been reported that the expression of TFPI-2 was down regulated in several invasive tumor cell lines, including choriocarcinoma, glioma, prostate cancer, melanoma and fibrosarcoma, moreover ectopic expression of this gene inhibits tumors growth and metastasis in vivo by regulating pericellular ECM remodeling and angiogenesis [5-10].