Patients who developed CHD were older, had longer duration of diabetes, more unfavourable lipid profile (LDL-C, HDL-C and TG), worse renal function, higher HbA1c, urinary ACR and WBC, lower Hb and were more likely to be treated with insulin and antihypertensive drugs at baseline that those who did not (Table 1). This evidence concerns the gene INS and coronary artery disorder.