Though we are unable to form a direct prediction of the TCC haplotype, we believe that our approach is comprehensive enough to have detected a true association within this region of the strength reported by Vaclavicek et al. Using 56 tagSNPs across high density coverage of 210 kb of the PRLR locus (25 kb upstream of first alternative exon E13 to 10 kb downstream of exon 11), we did not find an association between SNPs or haplotypes in PRLR and breast cancer risk. The gene discussed is PRLR; the disease is breast cancer.