The strongest associations between individual SNPs and breast cancer risk were with SNP34 (rs9466314) in "block 2" of PRL (co-dominant effect OR, 1.48; 95% CI, 1.00–2.18; p = 0.049) and SNP49 (rs34024951) in block 3 of PRLR (co-dominant effect OR, 0.85; 95% CI, 0.73–0.99; p = 0.032) (Table 1). This evidence concerns the gene PRLR and breast carcinoma.