Despite the high r-hGH dosage (mean dose 0,123 mg/Kg/d; range 0,8 mg- 1,4 mg), only 10 adverse events were reported in 4 patients, all of them in the r-hGH group (two cases each of joint pain, oedema and anemia and 1 case each of carpal tunnel syndrome, cholelithiasis, hypertriglyceridemia and hyperglycemia). This evidence concerns the gene GH1 and anemia.