All patients fulfilled the ACR criteria for fibromyalgia, the cut-off levels for severity (16/18 positive trigger points and FIQ>75) and duration of symptoms (>1 year), IGF-1 levels>250 ug/dL (three patients in the control group had IGF-1<150 ug/dL and undergone an ITT with a peak GH response above 5 ug/dL and had normal MNR) and completed the study. Here, GH1 is linked to fibromyalgia.