So far, efforts to characterize the Ag specificity of intracardiac CD8+ T cells in our infection model have been hampered by the findings that Dm28c T. cruzi strain did not present open reading frames for genes coding for ASP-2 antigens [48], which in other systems provide dominant epitopes recognized by cytotoxic CD8+ T cells [46,47]. Here, BACE1 is linked to infection.