Interestingly, they showed that acute infection is more severe in TLR2−/− TLR9−/− mice than in TLR9−/− mice or either TLR2−/−- [23] or TLR4-deficient mice [22], albeit not as much as in the overtly susceptible MyD88−/− mice [24]. The gene discussed is TLR9; the disease is infection.