Therefore, we investigated the contribution of IL12B to type 1 diabetes susceptibility, as thoroughly as possible, by genotyping a SNP (A1159C; rs3212227), two rare nsSNPs (rs3213096 and rs3213119), a microsatellite (D5S2941) and a set of tag SNPs for the IL12B region. This evidence concerns the gene IL12B and type 1 diabetes mellitus.