TPO and type 1 diabetes mellitus: For example, CTLA4 genotypes has a small effect overall in type 1 diabetes (OR = 1.20, 95% CI 1.13–1.27), but subclassification of cases with or without the thyroid peroxidase autoantibodies revealed an increased effect (OR = 1.49, 95% CI 1.29–1.72) for cases with autoantibodies (without autoantibodies OR = 1.16, 95% CI 1.10–1.24) [56].