IL10 and schistosomiasis: Mouse experimental schistosomiasis studies suggest that the development of effector Th1/Th2 and immuno-modulatory responses reflect the parasite's developmental stage (see [14] for review) so that Th1 responses predominate in the early acute phase followed by the emergence of Th2 responses (stimulated by egg antigens) and decrease in Th1 responses (down-modulated through an IL-10-dependent mechanism) [18].