In tumour homogenate [TH] there was no statistically significant variations of PRL mean levels during acute administration of goserelin neither post chronically treated: Basal 5.8 ± 1.2 ng/ml (n = 20); 30 min 6.9 ± 0.1 ng/ml (n = 20), P = 0.20; 60 min 5.6 ± 0.3 ng/ml (n = 20); at 90 min 6.8 ± 0.2 ng/ml (n = 20), P = 0.35. The gene discussed is PRL; the disease is neoplasm.