As a result of this rearrangement, the Rtn4r mouse gene is located between the Prodh gene (∼40-kb proximal) and the Zdhhc8 gene (∼70-kb distal) (Fig. 2A), both of which have been implicated by human genetic studies as strong candidate susceptibility genes for schizophrenia [21]–[23]. Here, ZDHHC8 is linked to schizophrenia.