Other genes have been implicated in AMD development, including complement component 2 (CF2) and factor B (BF),[15] toll-like receptor 4 (TLR4),[16] and potentially a sequence variant in hemicentin-1 (HMCN-1)[17], [18] which resides close to the CFH locus on 1q. The gene discussed is TLR4; the disease is age-related macular degeneration.