The association of single nucleotide polymorphisms (SNPs) in the CFH (Y402H, C1277T, rs1061170)[3]–[7] and LOC387715 (A69S, rs10490924)[8]–[11] and HTRA1 genes[12] with advanced AMD susceptibility have now been replicated in a number of independent studies. The gene discussed is CFH; the disease is age-related macular degeneration.