It is notable that the Lck protein is aberrantly expressed in several malignancies, including colon carcinoma, small cell lung carcinoma, and prostate carcinoma with a trend of preferential expression in metastatic lesions (Robinson et al, 1996; McCracken et al, 1997; Krystal et al, 1998; Lutz et al, 1998). The gene discussed is LCK; the disease is small cell lung carcinoma.