For example, among our current predictions are six genes (COL4A1, COL4A2, SPARC, BGN, DCM, and LUM) whose mutation may lead to phenotypes similar to Ehlers-Danlos syndrome (which is characterized by a range of problems related to skin, joints, eyes, and other areas), based on their co-expression and physical interactions with three proteins known to be involved in this disease (FN1, COL3A1, and COL1A2). The gene discussed is SPARC; the disease is Ehlers-Danlos syndrome.