CD40LG and systemic lupus erythematosus: There was evidence, however, of an association of high titres of IgG ACL and IgM ACL among the small number (n = 5, 5%) of women with SLE reporting three or more miscarriages (P = 0.001 and P = 0.009, respectively, when compared with (normal) expectation), and among women with SLE reporting three consecutive miscarriages (P = 0.03 and P = 0.05, respectively).