Its main signalling pathway is the FAK/Src and ERK pathway to promote cell mobility; inhibition of this integrin leads to cancer cell dormancy in biological models.71, 72 Integrin α5 β1 appears to be necessary, via the PI3K/AKT pathway, for the survival of dormant cancer cells.68 uPAR expression by BM DTC has also been linked to a poorer prognosis in a population of micrometastatic patients.16 The gene discussed is AKT1; the disease is cancer.