It is important to note that our previous pathogenic classification for G1738R was not driven by immunohistopathology results but rather by the observation of loss of the wild-type allele in both BRCA1 G1738R tumours studied, data we excluded in this study due to the observation that our loss of heterozygosity data on classified variants do not support the underlying assumptions of the model. The gene discussed is BRCA1; the disease is neoplasm.