EGF and hereditary pheochromocytoma-paraganglioma: VGSCs have been found to be regulated by growth factors, such as fibroblast growth factor (FGF), nerve growth factor (NGF), epidermal growth factor (EGF), in various human and rat cell lines, such as pheochromocytoma PC12 cells [15-17] and rat PCa Mat-LyLu cells [18,19].