TNF and colon carcinoma: JAK2 has been shown to be activated in response to a wide variety of stimuli [30] and AG-490 to block induced NOS2 expression in IL-1β/TNFα/IFNγ-stimulated human epithelial-like colon carcinoma DLD-1 cells [31] and in IFNγ/LPS stimulated RAW cells [32].