PRPF8 and Abnormal retinal morphology: Notably, transcripts of retinal disease genes, such as Crb1 (encoding Crumbs homolog 1), Abca4 (subfamily-D ATP-binding cassette member 4), Pde6a (phosphodiesterase 6A), Prpf8 (pre-mRNA processing factor 8) and Prpf31 (pre-mRNA processing factor 31 homolog), together with an additional 48 eye disease genes, are predicted to be targeted by these miRs (Additional data file 3).