The proposed mechanisms by which RF ablation decreases pain may involve: pain transmission inhibition by destroying sensory nerve fibres in the periosteum and bone cortex; reduction of lesion volume with decreased stimulation of sensory nerve fibres; destruction of tumour cells that are producing nerve-stimulating cytokines (tumour necrosis factor-alpha [TNF-α], interleukins, etc.)and inhibition of osteoclast activity [11, 12]. This evidence concerns the gene TNF and neoplasm.