HMOX1 and neurodegenerative disease: In particular, nuclear HO-1 localisation in astroglial cells was implicated in brain development and neurodegenerative diseases (Li Volti et al, 2004), in rat fetal lung cells exposed to hyperoxia as a chaperone or a nuclear messenger (Suttner et al, 1999) and in brown adipocyte as a transcription factor in adipogenesis (Giordano et al, 2000).