The effect of combining Aurora-A inhibition with IR is unknown, and the aim of this study was to evaluate the influence of inhibition of Aurora-A kinase of tumour radio-sensitivity by either a genetic inhibition using short interfering RNA (siRNA) targeting Aurora-A or a pharmacological approach using a selective inhibitor PHA680632 (Soncini et al, 2006). This evidence concerns the gene AURKA and neoplasm.