CYCS and colorectal cancer: This study is the in vivo continuation of our previous experiments with LCL-30, the cationic water-soluble analogue of C16-ceramide, in which we could demonstrate that LCL-30 accumulates in the mitochondria of SW403 colorectal cancer cells and induces mitochondrial swelling, cytochrome c release, caspase activation, and eventually cell death (Dindo et al, 2006).