EGFR and neoplasm: Oral BIBW 2992 induced tumour regression in mice carrying EGFR-overexpressing and HER2-expressing A431 xenografts, in mice carrying EGFR-overexpressing and HER2-expressing MDA-MB-453 xenografts, and in NCI-N87 gastric and SKOV-3 ovarian models at plasma concentrations of 80–280 nM (Boehringer-Ingelheim, data on file).