As the function of these critical cellular proteins can be impaired by common causes of chronic liver disease and HCC, including viral hepatitis B and C proteins [14-22], we suggest that disruption of pRb function, and to a lesser extend P21Cip1 and P53 in hepatocytes may represent an additional new mechanism of escape from TGFβ growth inhibition in the inflammatory milieu of chronic liver disease. This evidence concerns the gene RB1 and hepatocellular carcinoma.