In support of this idea, most of the upregulated genes in this category are enriched in immune cells (for example ABC1, Gimap4), whereas the downregulated genes are enriched in neural tissue (Uhm kinase 1, EphRa3), observations consistent with the inflammatory cell infiltrate and neuronal loss that characterize late stages of neurodegeneration in neuronal ceroid lipofuscinosis. This evidence concerns the gene GIMAP4 and neuronal ceroid lipofuscinosis.