WNK1 and hypertensive disorder: Only three of these loci have a 90% credible interval that excludes no risk due to ancestry: AGTR1, CYP4A11, and WNK1. The WNK1 and AGTR1 genes both show increased HTN risk with inheritance of the African allele, which is the direction that might be expected given that African Americans have a higher rate of HTN (we estimate an increased risk for HTN of 1.11 and 1.14 for inheritance of one copy of the African allele at these loci, respectively).