The role of MMP-7 in acute lung injury has been studied in mouse models of interstitial pulmonary diseases such as fibrosis: Mmp7−/− mice had suppressed pulmonary fibrosis caused by bleomycin (Li et al. 2002; Zuo et al. 2002), and it was accompanied by decreased neutrophilic inflammation and chemokines (e.g., KC) in the alveolar fluid (Li et al. 2002). This evidence concerns the gene CALCA and fibrosis.