While recent studies indicate that complete blockage of BACE1 activity may be associated with certain undesirable side-effects (also see "Putative Non-APP BACE1 Substrates" section below), important data demonstrates that in specific AD Tg models, partial reduction of BACE1 levels may improve cognitive deficits and amyloid neuropathology including Aβ deposition. This evidence concerns the gene BACE1 and Cognitive impairment.