This point is particularly interesting to note due to the fact that it has previously been shown in colorectal carcinoma that when endogenous sources of CXCL12 are epigenetically silenced, these cells more readily metastasize compared to those that engage in CXCR4/CXCL12 autocrine signaling [15]. This evidence concerns the gene CXCR4 and colorectal carcinoma.