To clarify whether substitutions in Mamu-B*08-restricted epitopes might affect the ability of Mamu-B*08-positive animals to control SIVmac239 infection, we next determined epitope sequences of viruses circulating in Mamu-B*08-positive ECs before and after CD8+ cell depletion, when SIV replication was effectively controlled (Fig. 6). Here, CD8A is linked to infection.