Although fenofibrate, Wy14 643, and CGZ inhibited antigen-induced leukotriene production from rat basophilic leukemia (RBL)-2H3 cells, these effects are likely to be PPAR-independent since PPARα mRNA was below detection [34] and the inhibition by CGZ was not prevented by a PPARγ antagonist or associated with nuclear translocation of the receptor [62]. This evidence concerns the gene PPARA and leukemia.