There was no difference in TTP according to sex (P=0.468), histology (P=0.676), EGFR positivity (by IHC) (P=0.267) and PS (P=0.437); conversely, patients who had never-smoked and patients who developed skin rash had significantly higher TTP (P=0.003 and P=0.006, respectively). This evidence concerns the gene EGFR and Skin rash.