Histone deacetylase 8 also associates with the inv(16) fusion protein, one of the most frequent chromosomal translocations found in acute myeloid leukaemia (AML), occurring in over 8% of AML cases (Durst et al, 2003, Waltregny et al, 2005). This evidence concerns the gene HDAC8 and acute myeloid leukemia.