CD8A and neoplasm: In addition, the numbers and cytolytic activity of peripheral NK cells [74-76] as well as average numbers of CD25-positive (activated) and total peripheral CD4+ T lymphocytes and CD8+ T lymphocytes [77,78] and their effector properties (i.e., TCR-induced cytokine production [79] and lytic function [28]) would be measured before initiation of cold water treatment (in 5–10 mice) and 60 days after the tumor inoculation in the experimental and control groups of mice.