The presence of mutations of the mitotic checkpoint regulators BUB1 and BUBR1 and amplification of Aurora-A/STK15 (also known as BTAK, Aurora 2, and AIK1) in a subset of human colon cancers have suggested that CIN results primarily from deregulation of DNA replication and mitotic-spindle checkpoints [3]. The gene discussed is AURKA; the disease is cervical squamous intraepithelial neoplasia.