CD4 and autoimmune lymphoproliferative syndrome: Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder characterized by autoimmune manifestations that predominantly involve blood cells, polyclonal accumulation of lymphocytes in the spleen and lymph nodes with lymphoadenomegaly and/or splenomegaly, expansion of TCRαβ+ CD4/CD8 double-negative (DN) T cells in the peripheral blood and defective in vitro apoptosis of mature lymphocytes induced by the Fas death receptor [1-4].