It is intriguing that the first ALPS patient homozygous for V410I harbored a heterozygous missense mutation in the tumor necrosis factor receptor-1 gene (TNFRSF1A), which is mutated in the TNF receptor-associated periodic fever syndrome (TRAPS) and may explain its clinical pattern [30]. The gene discussed is TNFRSF1A; the disease is TNF receptor 1-associated periodic fever syndrome.