After incubation of Wt-SOD1 and G93A-SOD1 neuroblastoma cells with the pneumococcal virulence factor pneumolysin for 3 hours, the G93A-SOD1 mutant cells showed a significantly decreased cell viability as evidenced by the WST-1 test (24.3 ± 9.6% of the living untreated cells) compared to the Wt-SOD1 cells (48.8 ± 19.5%; p < 0.0001, Fig. 1). Here, SOD1 is linked to neuroblastoma.