Hanum and colleagues recently demonstrated the induction of IP-10 expression in the brain of both CM-susceptible (C57BL/6) and CM-resistant (BALB/c) mice as early as 24 hours post-infection with Plasmodium berghei ANKA, and in KT-5 astrocyte cell line in vitro upon stimulation with a crude antigen of malaria parasites [33]. This evidence concerns the gene CXCL10 and infection.