Likewise, the minor allele of SNP rs3803662 in the TNRC9 locus also showed a nonsignificant trend with a larger number of first-degree relatives with breast cancer (on average, 0.23 in major allele homozygous patients versus 0.28 and 0.31 for heterozygous patients and minor allele homozygous patients, respectively). This evidence concerns the gene TOX3 and breast cancer.