Target genes involved in the Smad4-mediated tumour suppression in colorectal and in pancreatic carcinoma cells, such as E-cadherin [16], laminin-5 [18], VEGF and thrombospondin-1 [15], however, did not respond to Smad4-reexpression in C4-II cervical cancer cells. Here, SMAD4 is linked to exocrine pancreatic carcinoma.