The highest risk genotype was found to be the compound heterozygote HLA-DRB1*0301-DQB1*0201/HLA-DRB1*1501-DQB1*0602, while HLA-DRB1*0301-DQB1*0201-containing genotypes demonstrated a dose-dependent effect in increasing lupus susceptibility [25,28]. The gene discussed is HLA-DRB1; the disease is systemic lupus erythematosus.