HLA-B and systemic lupus erythematosus: Of the other 12 SNPs that were significantly associated with SLE (nominal p = 4.0 × 10−4 to 2.5 × 10−7; permuted p = 0.03 to <0.0001), one was located in the class I region between HLA-B and MICA, seven were located in the class III region, and four were situated in the class II region (Table 1; Figure S1).