However, as compared with normal tissues, the clusterin decreased in lung cancer (5.6±2.1 vs. 10.8±1.6, p = 0.005), breast cancer (7.1±2.7 vs. 10.5±1.7, p = 0.017), and ovarian cancer (6.8±3.0 vs. 10.5±1.7, p = 0.011) (Figure 3A, B and D). This evidence concerns the gene CLU and breast cancer.